Detection of Plasmodium falciparum-infected red blood cells by optical stretching.

نویسندگان

  • Jakob M A Mauritz
  • Teresa Tiffert
  • Rachel Seear
  • Franziska Lautenschläger
  • Alessandro Esposito
  • Virgilio L Lew
  • Jochen Guck
  • Clemens F Kaminski
چکیده

We present the application of a microfluidic optical cell stretcher to measure the elasticity of malaria-infected red blood cells. The measurements confirm an increase in host cell rigidity during the maturation of the parasite Plasmodium falciparum. The device combines the selectivity and sensitivity of single-cell elasticity measurements with a throughput that is higher than conventional single-cell techniques. The method has potential to detect early stages of infection with excellent sensitivity and high speed.

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عنوان ژورنال:
  • Journal of biomedical optics

دوره 15 3  شماره 

صفحات  -

تاریخ انتشار 2010